Polynucleotides (PDRN)

Polynucleotides (PDRN) are the latest breakthrough in regenerative aesthetics. These DNA fragments stimulate tissue repair, enhance hydration and promote skin regeneration, and they have become one of the treatments most valued by professionals.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides — the building blocks of DNA. When injected or applied to the skin, PDRN activates A2A purinergic receptors, triggering a cascade of regenerative responses. This includes increased fibroblast activity, enhanced collagen synthesis, improved blood flow, and reduced inflammation.

Unlike hyaluronic acid (which primarily hydrates) or botulinum toxin (which relaxes muscles), polynucleotides work by improving skin biology. They are biostimulators: they help the skin function more like younger skin.

Clinical Evidence

Clinical trials demonstrate that PDRN treatments improve skin elasticity by 44%, hydration by 38%, and overall skin quality scores by 41% after a course of 3-4 treatments. Results continue to improve for up to 6 months post-treatment as biostimulation continues.

For Aesthetic Professionals

Polynucleotides are one of the fastest-growing treatment categories in aesthetic medicine, and patient demand keeps rising. Adding PDRN to your treatment menu positions your clinic at the cutting edge.